› 8xaj

Electron Microscopy
3.29Å resolution

Cryo-EM structure of OSCA1.2-liposome-inside-in open state

Released:
DOI: 10.2210/pdb8xaj/pdb
PDB entry 8xaj coloured by chain, front view.
PDB entry 8xaj coloured by chain, side view.
PDB entry 8xaj coloured by chain, top view.
Source organism: Arabidopsis thaliana
Primary publication:
Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Han Y, Zhou Z, Jin R, Dai F, Ge Y, Ju X, Ma X, He S, Yuan L, Wang Y, Yang W, Yue X, Chen Z, Sun Y, Corry B, Cox CD, Zhang Y
Nature (2024)
PMID: 38570680
Related structures: EMD-38200

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178500 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium permeable stress-gated cation channel 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 771 amino acids
Theoretical weight: 87.99 KDa
Source organism: Arabidopsis thaliana
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5XEZ5 (Residues: 1-771; Coverage: 100%)
Gene names: At4g22120, CSC1, F1N20.220, OSCA1.2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PCW 7 x PCW
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.29Å
Relevant EMDB volumes: EMD-38200
Expression system: Homo sapiens

Quick links