› 8xb3

Electron Microscopy
2.8Å resolution

Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter

Released:
DOI: 10.2210/pdb8xb3/pdb
PDB entry 8xb3 coloured by chain, front view.
PDB entry 8xb3 coloured by chain, side view.
PDB entry 8xb3 coloured by chain, top view.
Source organisms:
Entry authors: Ji WM, Wu JX
Related structures: EMD-38209

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246342 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Maltose/maltodextrin-binding periplasmic protein; Sodium-dependent noradrenaline transporter Chain: A
Molecule details ›
Chain: A
Length: 1244 amino acids
Theoretical weight: 138.7 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P0AEX9 (Residues: 23-23, 27-392; Coverage: 98%)
  • Canonical: P23975 (Residues: 54-201, 202-617; Coverage: 91%)
Gene names: JW3994, NAT1, NET1, SLC6A2, SLC6A5, b4034, malE
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand YMN 1 x YMN
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-38209
Expression system: Homo sapiens

Quick links