› 8xb4

Electron Microscopy
2.92Å resolution

Structure of apo state of the human Norepinephrine Transporter

Released:
DOI: 10.2210/pdb8xb4/pdb
PDB entry 8xb4 coloured by chain, front view.
PDB entry 8xb4 coloured by chain, side view.
PDB entry 8xb4 coloured by chain, top view.
Source organisms:
Primary publication:
Substrate binding and inhibition mechanism of norepinephrine transporter.
Ji W, Miao A, Liang K, Liu J, Qi Y, Zhou Y, Duan X, Sun J, Lai L, Wu JX
Nature (2024)
PMID: 39143211
Related structures: EMD-38210

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246342 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Maltose/maltodextrin-binding periplasmic protein; Sodium-dependent noradrenaline transporter Chain: A
Molecule details ›
Chain: A
Length: 1244 amino acids
Theoretical weight: 138.7 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P0AEX9 (Residues: 23-23, 27-392; Coverage: 98%)
  • Canonical: P23975 (Residues: 54-201, 202-617; Coverage: 91%)
Gene names: JW3994, NAT1, NET1, SLC6A2, SLC6A5, b4034, malE
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.92Å
Relevant EMDB volumes: EMD-38210
Expression system: Homo sapiens

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