8xd7

Electron Microscopy
2.6Å resolution

Cryo-EM structure of inhibitor 25a bound human urea transporter A2.

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-231361 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urea transporter 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 397 amino acids
Theoretical weight: 43.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017
UniProt:
  • Canonical: Q15849 (Residues: 524-920; Coverage: 43%)
Gene names: HUT2, SLC14A2, UT2
Sequence domains: Urea transporter

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-38268
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017