› 8xi4

Electron Microscopy
3.4Å resolution

Structure of Eastern Equine Encephalitis VLP in complex with the receptor VLDLR LA1-2

Released:
DOI: 10.2210/pdb8xi4/pdb
PDB entry 8xi4 coloured by chain, front view.
PDB entry 8xi4 coloured by chain, side view.
PDB entry 8xi4 coloured by chain, top view.
Source organisms:
Primary publication:
The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes.
Cao D, Ma B, Cao Z, Xu X, Zhang X, Xiang Y
Nat Commun 15 6866 (2024)
PMID: 39127734
Related structures: EMD-38370

Function and Biology Details

Reaction catalysed: 
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-276242 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike glycoprotein E1 Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 441 amino acids
Theoretical weight: 47.98 KDa
Source organism: Eastern equine encephalitis virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q4QXJ7 (Residues: 802-1242; Coverage: 36%)
Sequence domains: Alphavirus E1 glycoprotein
Spike glycoprotein E2 Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 420 amino acids
Theoretical weight: 47.05 KDa
Source organism: Eastern equine encephalitis virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q4QXJ7 (Residues: 325-744; Coverage: 34%)
Sequence domains: Alphavirus E2 glycoprotein
Capsid protein Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 261 amino acids
Theoretical weight: 29.18 KDa
Source organism: Eastern equine encephalitis virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q4QXJ7 (Residues: 1-261; Coverage: 21%)
Sequence domains: Alphavirus core protein
Very low-density lipoprotein receptor Chains: M, N, O, P
Molecule details ›
Chains: M, N, O, P
Length: 83 amino acids
Theoretical weight: 9.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P98155 (Residues: 31-113; Coverage: 10%)
Gene name: VLDLR
Sequence domains: Low-density lipoprotein receptor domain class A

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-38370
Expression system: Homo sapiens

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