› 8xit

Electron Microscopy
3.2Å resolution

Cryo-EM structure of sheep VMAT2 dimer in an atypical fold

Released:
DOI: 10.2210/pdb8xit/pdb
PDB entry 8xit coloured by chain, front view.
PDB entry 8xit coloured by chain, side view.
PDB entry 8xit coloured by chain, top view.
Source organism: Ovis aries
Primary publication:
Engineering of a mammalian VMAT2 for cryo-EM analysis results in non-canonical protein folding.
Lyu Y, Fu C, Ma H, Su Z, Sun Z, Zhou X
Nat Commun 15 6511 (2024)
PMID: 39095428
Related structures: EMD-38389

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-269518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major facilitator superfamily (MFS) profile domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 630 amino acids
Theoretical weight: 68.59 KDa
Source organism: Ovis aries
Expression system: Komagataella pastoris
UniProt:
  • Canonical: A0A6P7DBQ8 (Residues: 1-357, 358-359, 360-517; Coverage: 100%)
Gene name: JEQ12_011695
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-38389
Expression system: Komagataella pastoris

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