8xjn

Electron Microscopy
3.06Å resolution

Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-273364 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Engineered miniGq Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 28.31 KDa
Source organism: synthetic construct
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 376 amino acids
Theoretical weight: 40.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
Antibody fragment scFv16 Chain: E
Thromboxane A2 receptor Chain: R

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.06Å
Relevant EMDB volumes: EMD-38402
Expression systems:
  • Spodoptera frugiperda
  • Trichoplusia ni