› › Function and Biology

Respiratory complex Peripheral Arm of CI, close form B, focus-refined map of type II, Wild type mouse under Cold Acclimation

Source organism: Mus musculus
Biochemical function: NADH dehydrogenase (ubiquinone) activity
Biological process: proton motive force-driven mitochondrial ATP synthesis
Cellular component: respiratory chain complex I

Quick links

EC 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating)

Reaction catalysed:
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Systematic name:
NADH:ubiquinone oxidoreductase
Alternative Name(s):
  • Coenzyme Q reductase
  • Complex 1 dehydrogenase
  • Complex I (NADH:Q1 oxidoreductase)
  • Complex I (electron transport chain)
  • Complex I (mitochondrial electron transport)
  • DPNH-coenzyme Q reductase
  • DPNH-ubiquinone reductase
  • Dihydronicotinamide adenine dinucleotide-coenzyme Q reductase
  • Electron transfer complex I
  • Mitochondrial electron transport complex 1
  • Mitochondrial electron transport complex I
  • NADH coenzyme Q1 reductase
  • NADH dehydrogenase (ubiquinone)
  • NADH-CoQ oxidoreductase
  • NADH-CoQ reductase
  • NADH-Q6 oxidoreductase
  • NADH-coenzyme Q oxidoreductase
  • NADH-coenzyme Q reductase
  • NADH-ubiquinone oxidoreductase
  • NADH-ubiquinone reductase
  • NADH-ubiquinone-1 reductase
  • NADH:ubiquinone oxidoreductase complex
  • Reduced nicotinamide adenine dinucleotide-coenzyme Q reductase
  • Type 1 dehydrogenase
  • Ubiquinone reductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF15880
Domain description: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF15880 (NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial) in NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial. Showing 1 copy in chain W [auth s].

PF07347
Domain description: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF07347 (NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7. Showing 1 copy in chain V [auth r].

PF05071
Domain description: NADH ubiquinone oxidoreductase subunit NDUFA12
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF05071 (NADH ubiquinone oxidoreductase subunit NDUFA12) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12. Showing 1 copy in chain U [auth q].

PF14987
Domain description: NADH dehydrogenase 1 alpha subcomplex subunit 3
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF14987 (NADH dehydrogenase 1 alpha subcomplex subunit 3) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3. Showing 1 copy in chain T [auth b].

PF15879
Domain description: NADH-ubiquinone oxidoreductase MWFE subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF15879 (NADH-ubiquinone oxidoreductase MWFE subunit) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1. Showing 1 copy in chain S [auth a].

PF06212
Domain description: GRIM-19 protein
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF06212 (GRIM-19 protein) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. Showing 1 copy in chain R [auth Z].

PF06747
Domain description: CHCH domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF06747 (CHCH domain) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8. Showing 1 copy in chain Q [auth X].

PF13233
Domain description: Complex1_LYR-like
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF13233 (Complex1_LYR-like) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6. Showing 1 copy in chain P [auth W].

PF04716
Domain description: ETC complex I subunit conserved region
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF04716 (ETC complex I subunit conserved region) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5. Showing 1 copy in chain O [auth V].

PF00550
Domain description: Phosphopantetheine attachment site
Occurring in:
  1. Acyl carrier protein, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF00550 (Phosphopantetheine attachment site) in Acyl carrier protein, mitochondrial. Showing 1 copy in chain N [auth T].

PF05047
Domain description: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF05047 (Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2. Showing 1 copy in chain M [auth S].

PF10276
Domain description: Zinc-finger domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF10276 (Zinc-finger domain) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial. Showing 1 copy in chain L [auth R].

PF04800
Domain description: NADH dehydrogenase ubiquinone Fe-S protein 4
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF04800 (NADH dehydrogenase ubiquinone Fe-S protein 4) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial. Showing 1 copy in chain K [auth Q].

PF05368
Domain description: NmrA-like family
Occurring in:
  1. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF05368 (NmrA-like family) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial. Showing 1 copy in chain J [auth P].

PF12838
Domain description: 4Fe-4S dicluster domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF12838 (4Fe-4S dicluster domain) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial. Showing 1 copy in chain I.

PF00146
Domain description: NADH dehydrogenase
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 1
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF00146 (NADH dehydrogenase) in NADH-ubiquinone oxidoreductase chain 1. Showing 1 copy in chain H.

PF09326
Domain description: NADH-ubiquinone oxidoreductase subunit G, C-terminal
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF09326 (NADH-ubiquinone oxidoreductase subunit G, C-terminal) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain G.

PF00384
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF00384 (Molybdopterin oxidoreductase) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain G.

PF22151
Domain description: NADH-ubiquinone oxidoreductase NDSU1/NuoG-like, 4Fe-4S domain
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF22151 (NADH-ubiquinone oxidoreductase NDSU1/NuoG-like, 4Fe-4S domain) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain G.

PF22117
Domain description: NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF22117 (NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain G.

PF10588
Domain description: NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF10588 (NADH-ubiquinone oxidoreductase-G iron-sulfur binding region) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain G.

PF13510
Domain description: 2Fe-2S iron-sulfur cluster binding domain
Occurring in:
  1. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF13510 (2Fe-2S iron-sulfur cluster binding domain) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain G.

PF10589
Domain description: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF10589 (NADH-ubiquinone oxidoreductase-F iron-sulfur binding region) in NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial. Showing 1 copy in chain F.

PF22461
Domain description: SLBB domain
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF22461 (SLBB domain) in NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial. Showing 1 copy in chain F.

PF01512
Domain description: Respiratory-chain NADH dehydrogenase 51 Kd subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF01512 (Respiratory-chain NADH dehydrogenase 51 Kd subunit) in NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial. Showing 1 copy in chain F.

PF01257
Domain description: Thioredoxin-like [2Fe-2S] ferredoxin
Occurring in:
  1. NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF01257 (Thioredoxin-like [2Fe-2S] ferredoxin) in NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial. Showing 1 copy in chain E.

PF00346
Domain description: Respiratory-chain NADH dehydrogenase, 49 Kd subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF00346 (Respiratory-chain NADH dehydrogenase, 49 Kd subunit) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial. Showing 1 copy in chain D.

PF00329
Domain description: Respiratory-chain NADH dehydrogenase, 30 Kd subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF00329 (Respiratory-chain NADH dehydrogenase, 30 Kd subunit) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial. Showing 1 copy in chain C.

PF01058
Domain description: NADH ubiquinone oxidoreductase, 20 Kd subunit
Occurring in:
  1. NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF01058 (NADH ubiquinone oxidoreductase, 20 Kd subunit) in NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial. Showing 1 copy in chain B.

PF00507
Domain description: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
Occurring in:
  1. NADH-ubiquinone oxidoreductase chain 3
The deposited structure of PDB entry 8xnw contains 1 copy of Pfam domain PF00507 (NADH-ubiquinone/plastoquinone oxidoreductase, chain 3) in NADH-ubiquinone oxidoreductase chain 3. Showing 1 copy in chain A.

Quick links