› 8xoq

X-ray diffraction
2.41Å resolution

Human Calcium and Integrin Binding Protein 2 (CIB2) Fusion to TMC1 CBD-1 domain at 2.4 Angstroms resolution

Released:
DOI: 10.2210/pdb8xoq/pdb
Model geometry
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PDB entry 8xoq coloured by chain, front view.
PDB entry 8xoq coloured by chain, side view.
PDB entry 8xoq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction.
Li Y, Chen J, Jiang W, Ye J, Zhang X, Wang C
Commun Biol 8 306 (2025)
PMID: 40000792

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-283835 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium and integrin-binding family member 2; Transmembrane channel-like protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 250 amino acids
Theoretical weight: 28.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q8TDI8 (Residues: 86-137; Coverage: 7%)
  • Canonical: O75838 (Residues: 1-187; Coverage: 100%)
Gene names: CIB2, KIP2, TMC1

Ligands and Environments

1 bound ligand:
Ligand MG 4 x MG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P21
Unit cell:
a: 32.065Å b: 121.849Å c: 62.208Å
α: 90° β: 91.74° γ: 90°
R-values:
R R work R free
0.203 0.201 0.242
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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