› 8xpx

X-ray diffraction
1.75Å resolution

The Crystal Structure of PARP12 from Biortus.

Released:
DOI: 10.2210/pdb8xpx/pdb
PDB entry 8xpx coloured by chain, front view.
PDB entry 8xpx coloured by chain, side view.
PDB entry 8xpx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wang F, Cheng W, Lv Z, Qi J, Shen Z

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190480 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein mono-ADP-ribosyltransferase PARP12 Chains: A, B
Molecule details ›
Chains: A, B
Length: 196 amino acids
Theoretical weight: 22.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9H0J9 (Residues: 489-684; Coverage: 28%)
Gene names: PARP12, ZC3HDC1
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain

Ligands and Environments

3 bound ligands:
Ligand EDO 2 x EDO
Ligand PEG 2 x PEG
Ligand ACT 7 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL45XU
Spacegroup: C2
Unit cell:
a: 93.94Å b: 74.93Å c: 61.49Å
α: 90° β: 113.835° γ: 90°
R-values:
R R work R free
0.165 0.164 0.194
Expression system: Spodoptera frugiperda

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