› 8xv9

Electron Microscopy
3.8Å resolution

Fedratinib-bound human SLC19A3

Released:
DOI: 10.2210/pdb8xv9/pdb
PDB entry 8xv9 coloured by chain, front view.
PDB entry 8xv9 coloured by chain, side view.
PDB entry 8xv9 coloured by chain, top view.
Source organisms:
Primary publication:
Substrate and drug recognition mechanisms of SLC19A3.
Dang Y, Zhang T, Pidathala S, Wang G, Wang Y, Chen N, Song C, Lee CH, Zhang Z
Cell Res (2024)
PMID: 38503960
Related structures: EMD-38693

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-272618 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble cytochrome b562; Thiamine transporter 2 Chain: A
Molecule details ›
Chain: A
Length: 607 amino acids
Theoretical weight: 67.91 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: Q9BZV2 (Residues: 11-496; Coverage: 98%)
Gene names: SLC19A3, cybC
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 2TA 1 x 2TA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-38693
Expression system: Homo sapiens

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