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Structure of SARS-CoV-2 BA.2.86 spike glycoprotein in complex with ACE2 (3-up state)

Source organisms:
Biochemical function: receptor ligand activity
Biological process: entry receptor-mediated virion attachment to host cell
Cellular component: virion membrane

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EC 3.4.17.23: Angiotensin-converting enzyme 2

Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Systematic name:
-
Alternative Name(s):
  • ACE-2
  • ACE2
  • Angiotensin converting enzyme 2
  • Angiotensin converting enzyme-2
  • HACE2
  • Tmem27

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01401
Domain description: Angiotensin-converting enzyme
Occurring in:
  1. Processed angiotensin-converting enzyme 2
The deposited structure of PDB entry 8xvm contains 1 copy of Pfam domain PF01401 (Angiotensin-converting enzyme) in Processed angiotensin-converting enzyme 2. Showing 1 copy in chain B [auth D].

PF01601
Domain description: Coronavirus spike glycoprotein S2
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 8xvm contains 1 copy of Pfam domain PF01601 (Coronavirus spike glycoprotein S2) in Spike glycoprotein. Showing 1 copy in chain A.

PF19209
Domain description: Coronavirus spike glycoprotein S1, C-terminal
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 8xvm contains 1 copy of Pfam domain PF19209 (Coronavirus spike glycoprotein S1, C-terminal) in Spike glycoprotein. Showing 1 copy in chain A.

PF09408
Domain description: Betacoronavirus spike glycoprotein S1, receptor binding
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 8xvm contains 1 copy of Pfam domain PF09408 (Betacoronavirus spike glycoprotein S1, receptor binding) in Spike glycoprotein. Showing 1 copy in chain A.

PF16451
Domain description: Betacoronavirus-like spike glycoprotein S1, N-terminal
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 8xvm contains 1 copy of Pfam domain PF16451 (Betacoronavirus-like spike glycoprotein S1, N-terminal) in Spike glycoprotein. Showing 1 copy in chain A.

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