› 8xw1

Electron Microscopy
4.49Å resolution

Cryo-EM structure of OSCA1.2-V335W-DDM state

Released:
DOI: 10.2210/pdb8xw1/pdb
PDB entry 8xw1 coloured by chain, front view.
PDB entry 8xw1 coloured by chain, side view.
PDB entry 8xw1 coloured by chain, top view.
Source organism: Arabidopsis thaliana
Primary publication:
Mechanical activation opens a lipid-lined pore in OSCA ion channels.
Han Y, Zhou Z, Jin R, Dai F, Ge Y, Ju X, Ma X, He S, Yuan L, Wang Y, Yang W, Yue X, Chen Z, Sun Y, Corry B, Cox CD, Zhang Y
Nature (2024)
PMID: 38570680
Related structures: EMD-38727

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium permeable stress-gated cation channel 1 Chain: A
Molecule details ›
Chain: A
Length: 777 amino acids
Theoretical weight: 88.7 KDa
Source organism: Arabidopsis thaliana
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5XEZ5 (Residues: 1-771; Coverage: 100%)
Gene names: At4g22120, CSC1, F1N20.220, OSCA1.2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.49Å
Relevant EMDB volumes: EMD-38727
Expression system: Homo sapiens

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