› 8xyi

Electron Microscopy
3.16Å resolution

Structure of CXCR3 in complex with VUF10661 (Receptor-ligand focused map)

Released:
DOI: 10.2210/pdb8xyi/pdb
PDB entry 8xyi coloured by chain, front view.
PDB entry 8xyi coloured by chain, side view.
PDB entry 8xyi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system.
Saha S, Sano FK, Sharma S, Ganguly M, Dalal A, Mishra S, Tiwari D, Akasaka H, Kobayashi TA, Roy N, Zaidi N, Itoh Y, Leurs R, Banerjee R, Shihoya W, Nureki O, Shukla AK
Nat Commun 16 3047 (2025)
PMID: 40155369
Related structures: EMD-38774

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-286616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-X-C chemokine receptor type 3 Chain: R
Molecule details ›
Chain: R
Length: 424 amino acids
Theoretical weight: 46.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49682 (Residues: 2-368; Coverage: 100%)
Gene names: CXCR3, GPR9
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

1 bound ligand:
Ligand A1LW1 1 x A1LW1
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.16Å
Relevant EMDB volumes: EMD-38774
Expression system: Spodoptera frugiperda

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