› 8xzb

Electron Microscopy
3.12Å resolution

The structure of fox ACE2 and SARS-CoV RBD complex

Released:
DOI: 10.2210/pdb8xzb/pdb
PDB entry 8xzb coloured by chain, front view.
PDB entry 8xzb coloured by chain, side view.
PDB entry 8xzb coloured by chain, top view.
Source organisms:
Primary publication:
The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses.
Chen J, Sun J, Xu Z, Li L, Kang X, Luo C, Wang Q, Guo X, Li Y, Liu K, Wu Y
Virol Sin (2024)
PMID: 38866203
Related structures: EMD-38792

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246511 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Angiotensin-converting enzyme Chain: A
Molecule details ›
Chain: A
Length: 613 amino acids
Theoretical weight: 71.03 KDa
Source organism: Vulpes vulpes
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A3Q7RAT9 (Residues: 1-613; Coverage: 76%)
Gene name: ACE2
Sequence domains: Angiotensin-converting enzyme
Spike protein S1 Chain: C
Molecule details ›
Chain: C
Length: 228 amino acids
Theoretical weight: 25.86 KDa
Source organism: Severe acute respiratory syndrome-related coronavirus
Expression system: Homo sapiens
UniProt:
  • Canonical: P59594 (Residues: 306-527; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-38792
Expression system: Homo sapiens

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