› 8y19

Electron Microscopy
2.3Å resolution

Closed conformation of HKU1-B S protein after incubation of the receptor

Released:
DOI: 10.2210/pdb8y19/pdb
PDB entry 8y19 coloured by chain, front view.
PDB entry 8y19 coloured by chain, side view.
PDB entry 8y19 coloured by chain, top view.
Source organism: Human coronavirus HKU1 (isolate N2)
Primary publication:
Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2.
Xia L, Zhang Y, Zhou Q
Cell Res (2024)
PMID: 38641728
Related structures: EMD-38828

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243802 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1290 amino acids
Theoretical weight: 143.48 KDa
Source organism: Human coronavirus HKU1 (isolate N2)
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14EB0 (Residues: 1-1290; Coverage: 95%)
Gene names: 3, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 51 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.3Å
Relevant EMDB volumes: EMD-38828
Expression system: Homo sapiens

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