› 8y1e

Electron Microscopy
2.7Å resolution

3up-TM conformation of HKU1-B S protein after incubation of the receptor

Released:
DOI: 10.2210/pdb8y1e/pdb
PDB entry 8y1e coloured by chain, front view.
PDB entry 8y1e coloured by chain, side view.
PDB entry 8y1e coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2.
Xia L, Zhang Y, Zhou Q
Cell Res (2024)
PMID: 38641728
Related structures: EMD-38833

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243703 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1290 amino acids
Theoretical weight: 143.48 KDa
Source organism: Human coronavirus HKU1 (isolate N2)
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14EB0 (Residues: 1-1290; Coverage: 95%)
Gene names: 3, S
Sequence domains:
Transmembrane protease serine 2 non-catalytic chain Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 384 amino acids
Theoretical weight: 42.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15393 (Residues: 109-492; Coverage: 78%)
Gene names: PRSS10, TMPRSS2
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 51 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-38833
Expression system: Homo sapiens

Quick links