› 8y2e

Electron Microscopy
3.03Å resolution

Cryo-EM structure of human dopamine transporter in complex with benztropine

Released:
DOI: 10.2210/pdb8y2e/pdb
PDB entry 8y2e coloured by chain, front view.
PDB entry 8y2e coloured by chain, side view.
PDB entry 8y2e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Dopamine reuptake and inhibitory mechanisms in human dopamine transporter.
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024)
PMID: 39112701
Related structures: EMD-38852

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274411 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium-dependent dopamine transporter Chain: A
Molecule details ›
Chain: A
Length: 555 amino acids
Theoretical weight: 61.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q01959 (Residues: 66-620; Coverage: 90%)
Gene names: DAT1, SLC6A3
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand CXQ 1 x CXQ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.03Å
Relevant EMDB volumes: EMD-38852
Expression system: Homo sapiens

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