› 8y6f

X-ray diffraction
2.01Å resolution

The crystal structure of MMPs cleavable human heavy chain ferritin

Released:
DOI: 10.2210/pdb8y6f/pdb
PDB entry 8y6f coloured by chain, front view.
PDB entry 8y6f coloured by chain, side view.
PDB entry 8y6f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Engineered protein cages with enhanced extracellular drug release for elevated antitumor efficacy.
Yan W, Li H, Ning J, Huang S, Jiang L, Xu P, Huang M, Yuan C
Int J Biol Macromol 267 131492 (2024)
PMID: 38604418

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 196 amino acids
Theoretical weight: 22.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02794 (Residues: 1-162, 163-182; Coverage: 100%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain

Ligands and Environments

3 bound ligands:
Ligand CL 4 x CL
Ligand FE 17 x FE
Ligand NA 4 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL10U2
Spacegroup: P42212
Unit cell:
a: 219.66Å b: 219.66Å c: 148.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.245 0.287
Expression system: Escherichia coli BL21(DE3)

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