Function and Biology Details
Reactions catalysed:
ATP + H(2)O = ADP + phosphate
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero 46-mer (preferred)
PDBe Complex ID:
PDB-CPX-249732 (preferred)
Entry contents:
27 distinct polypeptide molecules
5 distinct RNA molecules
5 distinct RNA molecules
Macromolecules (32 distinct):
Pre-mRNA-processing-splicing factor 8
Chain: C
Molecule details ›
Chain: C
Length: 2335 amino acids
Theoretical weight: 273.97 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 2335 amino acids
Theoretical weight: 273.97 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q6P2Q9 (Residues: 1-2335; Coverage: 100%)
Sequence domains:
116 kDa U5 small nuclear ribonucleoprotein component
Chain: D
Molecule details ›
Chain: D
Length: 972 amino acids
Theoretical weight: 109.56 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 972 amino acids
Theoretical weight: 109.56 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q15029 (Residues: 1-972; Coverage: 100%)
Sequence domains:
U5 small nuclear ribonucleoprotein 200 kDa helicase
Chain: E
Molecule details ›
U5 small nuclear ribonucleoprotein 40 kDa protein
Chain: F
Molecule details ›
Chain: F
Length: 357 amino acids
Theoretical weight: 39.36 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: WD domain, G-beta repeat
Length: 357 amino acids
Theoretical weight: 39.36 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q96DI7 (Residues: 1-357; Coverage: 100%)
Sequence domains: WD domain, G-beta repeat
Pre-mRNA-processing factor 6
Chain: G
Molecule details ›
Chain: G
Length: 941 amino acids
Theoretical weight: 107.09 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 941 amino acids
Theoretical weight: 107.09 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O94906 (Residues: 1-941; Coverage: 100%)
Sequence domains:
Thioredoxin-like protein 4B
Chain: H
Molecule details ›
Chain: H
Length: 149 amino acids
Theoretical weight: 17.03 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Mitosis protein DIM1
Length: 149 amino acids
Theoretical weight: 17.03 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9NX01 (Residues: 1-149; Coverage: 100%)
Sequence domains: Mitosis protein DIM1
Probable ATP-dependent RNA helicase DDX23
Chain: I
Molecule details ›
Chain: I
Length: 820 amino acids
Theoretical weight: 95.79 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 820 amino acids
Theoretical weight: 95.79 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9BUQ8 (Residues: 1-820; Coverage: 100%)
Sequence domains:
Small nuclear ribonucleoprotein-associated proteins B and B'
Chains: a, h, o
Molecule details ›
Chains: a, h, o
Length: 240 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: LSM domain
Length: 240 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P14678 (Residues: 1-240; Coverage: 100%)
Sequence domains: LSM domain
Small nuclear ribonucleoprotein Sm D1
Chains: b, i, p
Molecule details ›
Chains: b, i, p
Length: 119 amino acids
Theoretical weight: 13.31 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: LSM domain
Length: 119 amino acids
Theoretical weight: 13.31 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62314 (Residues: 1-119; Coverage: 100%)
Sequence domains: LSM domain
Small nuclear ribonucleoprotein Sm D2
Chains: c, j, q
Molecule details ›
Chains: c, j, q
Length: 118 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: LSM domain
Length: 118 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62316 (Residues: 1-118; Coverage: 100%)
Sequence domains: LSM domain
Small nuclear ribonucleoprotein Sm D3
Chains: d, k, r
Molecule details ›
Chains: d, k, r
Length: 126 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: LSM domain
Length: 126 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62318 (Residues: 1-126; Coverage: 100%)
Sequence domains: LSM domain
Small nuclear ribonucleoprotein E
Chains: e, l, s
Molecule details ›
Chains: e, l, s
Length: 92 amino acids
Theoretical weight: 10.82 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: LSM domain
Length: 92 amino acids
Theoretical weight: 10.82 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62304 (Residues: 1-92; Coverage: 100%)
Sequence domains: LSM domain
Small nuclear ribonucleoprotein F
Chains: f, m, t
Molecule details ›
Chains: f, m, t
Length: 86 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: LSM domain
Length: 86 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62306 (Residues: 1-86; Coverage: 100%)
Sequence domains: LSM domain
Small nuclear ribonucleoprotein G
Chains: g, n, u
Molecule details ›
Chains: g, n, u
Length: 76 amino acids
Theoretical weight: 8.51 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: LSM domain
Length: 76 amino acids
Theoretical weight: 8.51 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62308 (Residues: 1-76; Coverage: 100%)
Sequence domains: LSM domain
U4/U6 small nuclear ribonucleoprotein Prp31
Chain: L
Molecule details ›
Chain: L
Length: 499 amino acids
Theoretical weight: 55.53 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 499 amino acids
Theoretical weight: 55.53 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q8WWY3 (Residues: 1-499; Coverage: 100%)
Sequence domains:
U4/U6 small nuclear ribonucleoprotein Prp4
Chain: M
Molecule details ›
Chain: M
Length: 522 amino acids
Theoretical weight: 58.54 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 522 amino acids
Theoretical weight: 58.54 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O43172 (Residues: 1-522; Coverage: 100%)
Sequence domains:
U4/U6 small nuclear ribonucleoprotein Prp3
Chain: N
Molecule details ›
Chain: N
Length: 683 amino acids
Theoretical weight: 77.67 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 683 amino acids
Theoretical weight: 77.67 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O43395 (Residues: 1-683; Coverage: 100%)
Sequence domains:
NHP2-like protein 1
Chain: O
Molecule details ›
Chain: O
Length: 128 amino acids
Theoretical weight: 14.19 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Length: 128 amino acids
Theoretical weight: 14.19 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P55769 (Residues: 1-128; Coverage: 100%)
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Centrosomal AT-AC splicing factor
Chain: R
Molecule details ›
Chain: R
Length: 332 amino acids
Theoretical weight: 38.03 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Coiled coil protein 84
Length: 332 amino acids
Theoretical weight: 38.03 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q86UT8 (Residues: 1-332; Coverage: 100%)
Sequence domains: Coiled coil protein 84
Zinc finger matrin-type protein 5
Chain: V
Molecule details ›
Chain: V
Length: 170 amino acids
Theoretical weight: 20 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 170 amino acids
Theoretical weight: 20 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9UDW3 (Residues: 1-170; Coverage: 100%)
Sequence domains:
U11/U12 small nuclear ribonucleoprotein 35 kDa protein
Chain: W
Molecule details ›
Chain: W
Length: 246 amino acids
Theoretical weight: 29.51 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: RNA recognition motif
Length: 246 amino acids
Theoretical weight: 29.51 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q16560 (Residues: 1-246; Coverage: 100%)
Sequence domains: RNA recognition motif
U11/U12 small nuclear ribonucleoprotein 25 kDa protein
Chain: X
Molecule details ›
Chain: X
Length: 132 amino acids
Theoretical weight: 15.29 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Ubiquitin-like domain
Length: 132 amino acids
Theoretical weight: 15.29 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9BV90 (Residues: 1-132; Coverage: 100%)
Sequence domains: Ubiquitin-like domain
U11/U12 small nuclear ribonucleoprotein 48 kDa protein
Chain: Y
Molecule details ›
Chain: Y
Length: 339 amino acids
Theoretical weight: 40.04 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: U11-48K-like CHHC zinc finger
Length: 339 amino acids
Theoretical weight: 40.04 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q6IEG0 (Residues: 1-339; Coverage: 100%)
Sequence domains: U11-48K-like CHHC zinc finger
Programmed cell death protein 7
Chain: Z
Molecule details ›
Chain: Z
Length: 485 amino acids
Theoretical weight: 54.79 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Programmed cell death protein 7
Length: 485 amino acids
Theoretical weight: 54.79 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q8N8D1 (Residues: 1-485; Coverage: 100%)
Sequence domains: Programmed cell death protein 7
U4/U6.U5 tri-snRNP-associated protein 1
Chain: S
Molecule details ›
Chain: S
Length: 800 amino acids
Theoretical weight: 90.41 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 800 amino acids
Theoretical weight: 90.41 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O43290 (Residues: 1-800; Coverage: 100%)
Sequence domains:
Ubiquitin carboxyl-terminal hydrolase 39
Chain: U
Molecule details ›
Serine/threonine-protein kinase PRP4 homolog
Chain: Q
Molecule details ›
Chain: Q
Length: 1007 amino acids
Theoretical weight: 117.26 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Protein kinase domain
Length: 1007 amino acids
Theoretical weight: 117.26 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q13523 (Residues: 1-1007; Coverage: 100%)
Sequence domains: Protein kinase domain
pre-mRNA
Chain: A
Molecule details ›
Chain: A
Length: 280 nucleotides
Theoretical weight: 89.52 KDa
Length: 280 nucleotides
Theoretical weight: 89.52 KDa
U5 snRNA
Chain: B
Molecule details ›
Chain: B
Length: 117 nucleotides
Theoretical weight: 37.25 KDa
Sequence domains: U5 spliceosomal RNA
Length: 117 nucleotides
Theoretical weight: 37.25 KDa
Sequence domains: U5 spliceosomal RNA
U4atac snRNA
Chain: J
Molecule details ›
Chain: J
Length: 131 nucleotides
Theoretical weight: 42.05 KDa
Sequence domains: U4atac minor spliceosomal RNA
Length: 131 nucleotides
Theoretical weight: 42.05 KDa
Sequence domains: U4atac minor spliceosomal RNA
U6atac snRNA
Chain: K
Molecule details ›
Chain: K
Length: 125 nucleotides
Theoretical weight: 40.22 KDa
Sequence domains: U6atac minor spliceosomal RNA
Length: 125 nucleotides
Theoretical weight: 40.22 KDa
Sequence domains: U6atac minor spliceosomal RNA
U11 snRNA
Chain: P
Molecule details ›
Chain: P
Length: 135 nucleotides
Theoretical weight: 43.51 KDa
Sequence domains: U11 spliceosomal RNA
Length: 135 nucleotides
Theoretical weight: 43.51 KDa
Sequence domains: U11 spliceosomal RNA