› 8y8g

Electron Microscopy
3.23Å resolution

Structure of HCoV-HKU1C spike in the glycan-activated-1up conformation

Released:
DOI: 10.2210/pdb8y8g/pdb
PDB entry 8y8g coloured by chain, front view.
PDB entry 8y8g coloured by chain, side view.
PDB entry 8y8g coloured by chain, top view.
Source organism: Human coronavirus HKU1 (isolate N5)
Primary publication:
TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024)
PMID: 38964329
Related structures: EMD-39045

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1263 amino acids
Theoretical weight: 140.24 KDa
Source organism: Human coronavirus HKU1 (isolate N5)
Expression system: Homo sapiens
UniProt:
  • Canonical: Q0ZME7 (Residues: 14-1276; Coverage: 94%)
Gene names: 3, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 20 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.23Å
Relevant EMDB volumes: EMD-39045
Expression system: Homo sapiens

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