› 8y94

Electron Microscopy
3.29Å resolution

Structure of Apo human norepinephrine transporter NET

Released:
DOI: 10.2210/pdb8y94/pdb
PDB entry 8y94 coloured by chain, front view.
PDB entry 8y94 coloured by chain, side view.
PDB entry 8y94 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Dimerization and antidepressant recognition at noradrenaline transporter.
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024)
PMID: 38750358
Related structures: EMD-39069

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273415 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium-dependent noradrenaline transporter Chains: A, C
Molecule details ›
Chains: A, C
Length: 617 amino acids
Theoretical weight: 69.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23975 (Residues: 1-617; Coverage: 100%)
Gene names: NAT1, NET1, SLC6A2, SLC6A5
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.29Å
Relevant EMDB volumes: EMD-39069
Expression system: Homo sapiens

Quick links