› 8yfn

X-ray diffraction
2.3Å resolution

Crystal structure of FIP200 claw in complex with TNIP1_FIR_pS123 peptide with an elongated C terminus

Released:
DOI: 10.2210/pdb8yfn/pdb
PDB entry 8yfn coloured by chain, front view.
PDB entry 8yfn coloured by chain, side view.
PDB entry 8yfn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for TNIP1 binding to FIP200 during mitophagy.
Wu S, Li M, Wang L, Yang L, Cui J, Li F, Wang Q, Shi Y, Lv M
J Biol Chem 107605 (2024)
PMID: 39059492

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-250337 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
RB1-inducible coiled-coil protein 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 105 amino acids
Theoretical weight: 12.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TDY2 (Residues: 1490-1594; Coverage: 7%)
Gene names: KIAA0203, RB1CC1, RBICC
Sequence domains: Autophagy-related protein 11
TNFAIP3-interacting protein 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 16 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15025 (Residues: 118-133; Coverage: 3%)
Gene names: KIAA0113, NAF1, TNIP1

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand GOL 2 x GOL
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P43
Unit cell:
a: 51.369Å b: 51.369Å c: 85.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.188 0.236
Expression systems:
  • Escherichia coli
  • Not provided

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