› 8ygu

Electron Microscopy
3.13Å resolution

Cryo-EM structure of simian rotavirus SA11 VP4 in complex with nAb 7H13-I54G mutant (right side)

Released:
DOI: 10.2210/pdb8ygu/pdb
PDB entry 8ygu coloured by chain, front view.
PDB entry 8ygu coloured by chain, side view.
PDB entry 8ygu coloured by chain, top view.
Source organisms:
Primary publication:
A single residue switch mediates the broad neutralization of Rotaviruses.
Huang Y, Song F, Zeng Y, Sun H, Sheng R, Wang X, Liu L, Luo G, Jiang Y, Chen Y, Zhang M, Zhang S, Gu Y, Yu H, Li S, Li T, Zheng Q, Ge S, Zhang J, Xia N
Nat Commun 16 838 (2025)
PMID: 39833145
Related structures: EMD-39264

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-285082 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Outer capsid protein VP4 Chains: A, C
Molecule details ›
Chains: A, C
Length: 779 amino acids
Theoretical weight: 87.15 KDa
Source organism: Rotavirus A
Outer capsid protein VP4 Chain: B
Molecule details ›
Chain: B
Length: 581 amino acids
Theoretical weight: 64.86 KDa
Source organism: Rotavirus A
Antibody 7H13-I54G mutant heavy chain Chain: H
Antibody 7H13-I54G mutant light chain Chain: L

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.13Å
Relevant EMDB volumes: EMD-39264
Expression system: Homo sapiens

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