› 8yhf

X-ray diffraction
1.4Å resolution

The Crystal Structure of the Type I TGF beta receptor from Biortus.

Released:
DOI: 10.2210/pdb8yhf/pdb
PDB entry 8yhf coloured by chain, front view.
PDB entry 8yhf coloured by chain, side view.
PDB entry 8yhf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wang F, Cheng W, Lv Z, Meng Q, Xu Y

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-1 Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 38.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P36897 (Residues: 162-503; Coverage: 73%)
Gene names: ALK5, SKR4, TGFBR1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand A1D6I 1 x A1D6I
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL45XU
Spacegroup: P212121
Unit cell:
a: 42.196Å b: 76.764Å c: 89.707Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.166 0.192
Expression system: Spodoptera frugiperda

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