› 8ykv

Electron Microscopy
2.48Å resolution

Cryo-EM structure of succinate receptor SUCR1 bound to compound 31

Released:
DOI: 10.2210/pdb8ykv/pdb
PDB entry 8ykv coloured by chain, front view.
PDB entry 8ykv coloured by chain, side view.
PDB entry 8ykv coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE
Cell Res (2024)
PMID: 38834763
Related structures: EMD-39373

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-244812 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.41 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P54311 (Residues: 1-340; Coverage: 100%)
Gene name: Gnb1
Sequence domains: WD domain, G-beta repeat
Antibody fragment ScFv16 Chain: E
Molecule details ›
Chain: E
Length: 247 amino acids
Theoretical weight: 26.31 KDa
Source organism: synthetic construct
Expression system: Trichoplusia ni
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Molecule details ›
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Bos taurus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P63212 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Sequence domains: GGL domain
Succinate receptor 1 Chain: R
Molecule details ›
Chain: R
Length: 334 amino acids
Theoretical weight: 38.73 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9BXA5 (Residues: 1-334; Coverage: 100%)
Gene names: GPR91, SUCNR1
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

1 bound ligand:
Ligand A1LYV 1 x A1LYV
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.48Å
Relevant EMDB volumes: EMD-39373
Expression system: Trichoplusia ni

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