› 8ymf

X-ray diffraction
1.02Å resolution

BRD4-BD1 in complex with 7-[2-(cyclopropylmethoxy)phenyl]-5-methyl-2-[(1-methylsulfonyl-4-piperidyl)methyl]pyrazolo[4,3-c]pyridin-4-one

Released:
DOI: 10.2210/pdb8ymf/pdb
Model geometry
Fit model/data
PDB entry 8ymf coloured by chain, front view.
PDB entry 8ymf coloured by chain, side view.
PDB entry 8ymf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sasaki C, Miyaguchi I, Hagihara S, Ishizawa K, Endo J

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 15.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand A1LZB 1 x A1LZB
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 41.03Å b: 52.37Å c: 57.94Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.148 0.147 0.171
Expression system: Escherichia coli

Quick links