› 8yo0

X-ray diffraction
1.3Å resolution

Crystal Structure of Human Rab23 Y79del in Complex with GDP

Released:
DOI: 10.2210/pdb8yo0/pdb
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PDB entry 8yo0 coloured by chain, front view.
PDB entry 8yo0 coloured by chain, side view.
PDB entry 8yo0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for Rab23 activation and a loss-of-function mutation in Carpenter Syndrome.
Chau YY, Liang H, Tung WL, Hor CHH, Aik WS
J Biol Chem 108036 (2024)
PMID: 39615683

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-281933 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-23 Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 18.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ULC3 (Residues: 7-172; Coverage: 70%)
Gene names: HSPC137, RAB23
Sequence domains: Ras family

Ligands and Environments

2 bound ligands:
Ligand GDP 1 x GDP
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU FR-X
Spacegroup: P212121
Unit cell:
a: 40.787Å b: 51.606Å c: 74.597Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.158 0.186
Expression system: Escherichia coli

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