› 8ypk

Electron Microscopy
2.7Å resolution

Function and Biology Details

Reaction catalysed: 
Cleavage of peptide bonds with very broad specificity.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 28-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126710 (preferred)
Entry contents:
14 distinct polypeptide molecules
Macromolecules (14 distinct):
Proteasome subunit beta type-6 Chains: A, F
Molecule details ›
Chains: A, F
Length: 205 amino acids
Theoretical weight: 22.01 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q60692 (Residues: 34-238; Coverage: 86%)
Gene names: Lmp19, Psmb6
Sequence domains: Proteasome subunit
Proteasome subunit alpha type-2 Chains: P, b
Molecule details ›
Chains: P, b
Length: 234 amino acids
Theoretical weight: 25.96 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P49722 (Residues: 1-234; Coverage: 100%)
Gene names: Lmpc3, Psma2
Sequence domains:
Proteasome subunit alpha type-7 Chains: I, N
Molecule details ›
Chains: I, N
Length: 248 amino acids
Theoretical weight: 27.9 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9Z2U0 (Residues: 1-248; Coverage: 100%)
Gene name: Psma7
Sequence domains:
Proteasome subunit alpha type-6 Chains: K, R
Molecule details ›
Chains: K, R
Length: 246 amino acids
Theoretical weight: 27.41 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9QUM9 (Residues: 1-246; Coverage: 100%)
Gene name: Psma6
Sequence domains:
Proteasome subunit beta type-2 Chains: T, V
Molecule details ›
Chains: T, V
Length: 201 amino acids
Theoretical weight: 22.94 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9R1P3 (Residues: 1-201; Coverage: 100%)
Gene name: Psmb2
Sequence domains: Proteasome subunit
Proteasome subunit beta type-1 Chains: S, X
Molecule details ›
Chains: S, X
Length: 240 amino acids
Theoretical weight: 26.41 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: O09061 (Residues: 1-240; Coverage: 100%)
Gene name: Psmb1
Sequence domains: Proteasome subunit
Proteasome subunit beta type-5 Chains: C, D
Molecule details ›
Chains: C, D
Length: 205 amino acids
Theoretical weight: 22.55 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: O55234 (Residues: 60-264; Coverage: 78%)
Gene name: Psmb5
Sequence domains: Proteasome subunit
Proteasome subunit alpha type-3 Chains: J, Q
Molecule details ›
Chains: J, Q
Length: 255 amino acids
Theoretical weight: 28.44 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: O70435 (Residues: 1-255; Coverage: 100%)
Gene name: Psma3
Sequence domains:
Proteasome subunit alpha type-1 Chains: G, L
Molecule details ›
Chains: G, L
Length: 263 amino acids
Theoretical weight: 29.59 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9R1P4 (Residues: 1-263; Coverage: 100%)
Gene name: Psma1
Sequence domains:
Proteasome subunit alpha type-5 Chains: H, M
Molecule details ›
Chains: H, M
Length: 241 amino acids
Theoretical weight: 26.44 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9Z2U1 (Residues: 1-241; Coverage: 100%)
Gene name: Psma5
Sequence domains:
Proteasome subunit alpha type-4 Chains: O, Z
Molecule details ›
Chains: O, Z
Length: 261 amino acids
Theoretical weight: 29.51 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9R1P0 (Residues: 1-261; Coverage: 100%)
Gene name: Psma4
Sequence domains:
Proteasome subunit beta type-7 Chains: B, E
Molecule details ›
Chains: B, E
Length: 234 amino acids
Theoretical weight: 25.28 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P70195 (Residues: 44-277; Coverage: 85%)
Gene names: Mmc14, Psmb7
Sequence domains:
Proteasome subunit beta type-4 Chains: W, a
Molecule details ›
Chains: W, a
Length: 264 amino acids
Theoretical weight: 29.14 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P99026 (Residues: 1-264; Coverage: 100%)
Gene names: Lmp3, Psmb4
Sequence domains: Proteasome subunit
Proteasome subunit beta type-3 Chains: U, Y
Molecule details ›
Chains: U, Y
Length: 205 amino acids
Theoretical weight: 22.99 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9R1P1 (Residues: 1-205; Coverage: 100%)
Gene name: Psmb3
Sequence domains: Proteasome subunit

Ligands and Environments

1 bound ligand:
Ligand A1L0C 4 x A1L0C
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-39482

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