› 8yr4

Electron Microscopy
3.1Å resolution

Cryo-EM structure of the human ABCB6 in complex with Cd(II):Phytochelatin 2

Released:
DOI: 10.2210/pdb8yr4/pdb
PDB entry 8yr4 coloured by chain, front view.
PDB entry 8yr4 coloured by chain, side view.
PDB entry 8yr4 coloured by chain, top view.
Source organisms:
Primary publication:
Cryo-EM structure of cadmium-bound human ABCB6.
Choi SH, Lee SS, Lee HY, Kim S, Kim JW, Jin MS
OpenAccess logo Commun Biol 7 672 (2024)
PMID: 38822018
Related structures: EMD-39535

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + heme(Side 1) = ADP + phosphate + heme(Side 2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-251789 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-binding cassette sub-family B member 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 637 amino acids
Theoretical weight: 71.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NP58 (Residues: 206-842; Coverage: 76%)
Gene names: ABCB6, MTABC3, PRP, UMAT
Sequence domains:
Phytochelatin 2 Chains: F, H, I, J
Molecule details ›
Chains: F, H, I, J
Length: 5 amino acids
Theoretical weight: 540 Da
Source organism: Tracheophyta
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand FGA 2 x FGA
Ligand CD 1 x CD
1 modified residue:
Ligand FGA 4 x FGA

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-39535
Expression systems:
  • Spodoptera frugiperda
  • Not provided

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