› 8ysx

Electron Microscopy
2.2Å resolution

Function and Biology Details

Reaction catalysed: 
Cleavage of peptide bonds with very broad specificity.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 28-mer (preferred)
PDBe Complex ID:
PDB-CPX-269622 (preferred)
Entry contents:
14 distinct polypeptide molecules
Macromolecules (14 distinct):
Proteasome subunit beta Chains: A, F
Molecule details ›
Chains: A, F
Length: 199 amino acids
Theoretical weight: 21.24 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0T7K4 (Residues: 11-209; Coverage: 95%)
Gene name: PSMB9
Sequence domains: Proteasome subunit
Proteasome subunit alpha type Chains: G, L
Molecule details ›
Chains: G, L
Length: 263 amino acids
Theoretical weight: 29.52 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8I3PML0 (Residues: 1-263; Coverage: 100%)
Gene names: LOC119864569, PSMA1
Sequence domains:
Proteasome subunit alpha type Chains: H, M
Molecule details ›
Chains: H, M
Length: 241 amino acids
Theoretical weight: 26.44 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0NHD1 (Residues: 1-241; Coverage: 100%)
Gene name: PSMA5
Sequence domains:
Proteasome subunit alpha type Chains: I, N
Molecule details ›
Chains: I, N
Length: 248 amino acids
Theoretical weight: 27.91 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0TD63 (Residues: 1-248; Coverage: 100%)
Gene name: PSMA7
Sequence domains:
Proteasome subunit alpha type Chains: O, Z
Molecule details ›
Chains: O, Z
Length: 261 amino acids
Theoretical weight: 29.52 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0TIY6 (Residues: 1-261; Coverage: 100%)
Gene name: PSMA4
Sequence domains:
Proteasome subunit alpha type Chains: K, R
Molecule details ›
Chains: K, R
Length: 246 amino acids
Theoretical weight: 27.42 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0SR54 (Residues: 1-246; Coverage: 100%)
Gene name: PRORP
Sequence domains:
Proteasome subunit beta Chains: T, V
Molecule details ›
Chains: T, V
Length: 201 amino acids
Theoretical weight: 22.81 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0QE86 (Residues: 1-201; Coverage: 100%)
Gene name: PSMB2
Sequence domains: Proteasome subunit
Proteasome subunit beta Chains: U, Y
Molecule details ›
Chains: U, Y
Length: 205 amino acids
Theoretical weight: 23 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0M3N7 (Residues: 1-205; Coverage: 100%)
Gene name: PSMB3
Sequence domains: Proteasome subunit
Proteasome subunit beta Chains: W, a
Molecule details ›
Chains: W, a
Length: 264 amino acids
Theoretical weight: 29.19 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0MRG6 (Residues: 1-264; Coverage: 100%)
Gene name: PSMB4
Sequence domains: Proteasome subunit
Proteasome subunit beta type-8 Chains: C, D
Molecule details ›
Chains: C, D
Length: 204 amino acids
Theoretical weight: 22.73 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: Q5W416 (Residues: 73-276; Coverage: 74%)
Gene name: PSMB8
Sequence domains: Proteasome subunit
Proteasome subunit alpha type Chains: P, b
Molecule details ›
Chains: P, b
Length: 234 amino acids
Theoretical weight: 25.93 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0QRK5 (Residues: 1-234; Coverage: 100%)
Gene name: PSMA2
Sequence domains:
Proteasome subunit beta Chains: S, X
Molecule details ›
Chains: S, X
Length: 241 amino acids
Theoretical weight: 26.43 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0N5D2 (Residues: 1-241; Coverage: 100%)
Gene name: PSMB1
Sequence domains: Proteasome subunit
Proteasome subunit alpha type Chains: J, Q
Molecule details ›
Chains: J, Q
Length: 255 amino acids
Theoretical weight: 28.48 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0R9W7 (Residues: 1-255; Coverage: 100%)
Gene name: PSMA3
Sequence domains:
Proteasome subunit beta Chains: B, E
Molecule details ›
Chains: B, E
Length: 234 amino acids
Theoretical weight: 24.88 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: A0A8C0SLB3 (Residues: 40-273; Coverage: 86%)
Gene name: PSMB10
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand A1L0D 4 x A1L0D
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.2Å
Relevant EMDB volumes: EMD-39565

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