› 8yvv

X-ray diffraction
2.25Å resolution

The Crystal Structure of BTK from Biortus

Released:
DOI: 10.2210/pdb8yvv/pdb
PDB entry 8yvv coloured by chain, front view.
PDB entry 8yvv coloured by chain, side view.
PDB entry 8yvv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wang F, Cheng W, Yuan Z, Lin D, Pan W

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170301 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase BTK Chains: A, B
Molecule details ›
Chains: A, B
Length: 266 amino acids
Theoretical weight: 31.15 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q06187 (Residues: 394-659; Coverage: 40%)
Gene names: AGMX1, ATK, BPK, BTK
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

3 bound ligands:
Ligand PEG 1 x PEG
Ligand EDO 4 x EDO
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P212121
Unit cell:
a: 46.686Å b: 102.995Å c: 117.543Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.266
Expression system: Spodoptera frugiperda

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