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Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
The deposited structure of PDB entry 8yw5 contains 7 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. Showing 7 copies in chain D [auth B].

PF00002
Domain description: 7 transmembrane receptor (Secretin family)
Occurring in:
  1. Glucagon receptor
The deposited structure of PDB entry 8yw5 contains 1 copy of Pfam domain PF00002 (7 transmembrane receptor (Secretin family)) in Glucagon receptor. Showing 1 copy in chain B [auth R].

PF02793
Domain description: Hormone receptor domain
Occurring in:
  1. Glucagon receptor
The deposited structure of PDB entry 8yw5 contains 1 copy of Pfam domain PF02793 (Hormone receptor domain) in Glucagon receptor. Showing 1 copy in chain B [auth R].

PF00631
Domain description: GGL domain
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
The deposited structure of PDB entry 8yw5 contains 1 copy of Pfam domain PF00631 (GGL domain) in Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2. Showing 1 copy in chain E [auth G].

PF00503
Domain description: G-protein alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
The deposited structure of PDB entry 8yw5 contains 1 copy of Pfam domain PF00503 (G-protein alpha subunit) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain C [auth A].

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