› 8yww

Electron Microscopy
2.7Å resolution

The structure of HKU1-B S protein with bsAb1

Released:
DOI: 10.2210/pdb8yww/pdb
PDB entry 8yww coloured by chain, front view.
PDB entry 8yww coloured by chain, side view.
PDB entry 8yww coloured by chain, top view.
Source organisms:
Primary publication:
A novel bispecific antibody targeting two overlapping epitopes in RBD improves neutralizing potency and breadth against SARS-CoV-2.
Sun H, Xia L, Li J, Zhang Y, Zhang G, Huang P, Wang X, Cui Y, Fang T, Fan P, Zhou Q, Chi X, Yu C
Emerg Microbes Infect 13 2373307 (2024)
PMID: 38953857
Related structures: EMD-39645

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-279765 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1210 amino acids
Theoretical weight: 134.1 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1210; Coverage: 95%)
Gene names: 2, S
Sequence domains:
H4B6 heavy chain Chains: E, G
Molecule details ›
Chains: E, G
Length: 218 amino acids
Theoretical weight: 23.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
H4B6 light chain Chains: D, F
Molecule details ›
Chains: D, F
Length: 212 amino acids
Theoretical weight: 23.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
the scfv of H4D12 Chain: H
Molecule details ›
Chain: H
Length: 245 amino acids
Theoretical weight: 26.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-39645
Expression system: Homo sapiens

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