› 8z3s

Electron Microscopy
3.9Å resolution

Activation mechanism and novel binding site of the BKCa channel activator CTIBD

Released:
DOI: 10.2210/pdb8z3s/pdb
PDB entry 8z3s coloured by chain, front view.
PDB entry 8z3s coloured by chain, side view.
PDB entry 8z3s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Activation mechanism and novel binding sites of the BKCa channel activator CTIBD.
Lee N, Kim S, Lee NY, Jo H, Jeong P, Pagire HS, Pagire SH, Ahn JH, Jin MS, Park CS
Life Sci Alliance 7 (2024)
PMID: 39089879
Related structures: EMD-39753

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171393 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-activated potassium channel subunit alpha-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1114 amino acids
Theoretical weight: 125.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12791 (Residues: 66-1179; Coverage: 90%)
  • Best match: Q12791-3 (Residues: 66-1183)
Gene names: KCNMA, KCNMA1, SLO
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand A1L04 8 x A1L04
Ligand Y01 4 x Y01
Ligand MG 4 x MG
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-39753
Expression system: Homo sapiens

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