8z98

Electron Microscopy
2.52Å resolution

Cryo-EM structure of Thogoto virus polymerase in a transcription reception conformation

Released:

Function and Biology Details

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-271680 (preferred)
Entry contents:
3 distinct polypeptide molecules
1 distinct RNA molecule
Macromolecules (4 distinct):
Polymerase acidic protein Chain: A
Molecule details ›
Chain: A
Length: 622 amino acids
Theoretical weight: 71.62 KDa
Source organism: Thogoto virus (isolate SiAr 126)
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27194 (Residues: 1-622; Coverage: 100%)
Gene name: Segment 3
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
RNA-directed RNA polymerase catalytic subunit Chain: B
Molecule details ›
Chain: B
Length: 710 amino acids
Theoretical weight: 81.43 KDa
Source organism: Thogoto virus (isolate SiAr 126)
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O41353 (Residues: 1-710; Coverage: 100%)
Gene name: Segment 2
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Polymerase basic protein 2 Chain: C
RNA (5'-R(P*GP*CP*AP*AP*AP*AP*AP*CP*A)-3') Chain: D

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.52Å
Relevant EMDB volumes: EMD-39856
Expression system: Spodoptera frugiperda