› 8z9a

Electron Microscopy
3Å resolution

Cryo-EM structure of the insect olfactory receptor OR5-Orco heterocomplex from Acyrthosiphon pisum bound with geranyl acetate

Released:
DOI: 10.2210/pdb8z9a/pdb
PDB entry 8z9a coloured by chain, front view.
PDB entry 8z9a coloured by chain, side view.
PDB entry 8z9a coloured by chain, top view.
Source organism: Acyrthosiphon pisum
Primary publication:
Structural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex.
Wang Y, Qiu L, Wang B, Guan Z, Dong Z, Zhang J, Cao S, Yang L, Wang B, Gong Z, Zhang L, Ma W, Liu Z, Zhang D, Wang G, Yin P
Science 384 1453-1460 (2024)
PMID: 38870272
Related structures: EMD-39858

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-245942 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Odorant receptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 463 amino acids
Theoretical weight: 52.92 KDa
Source organism: Acyrthosiphon pisum
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1S6J137 (Residues: 1-463; Coverage: 100%)
Gene name: Orco
Sequence domains: 7tm Odorant receptor
Odorant receptor Chain: D
Molecule details ›
Chain: D
Length: 367 amino acids
Theoretical weight: 42.45 KDa
Source organism: Acyrthosiphon pisum
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1S6J146 (Residues: 1-367; Coverage: 100%)
Gene name: OR5
Sequence domains: 7tm Odorant receptor

Ligands and Environments

2 bound ligands:
Ligand PC1 7 x PC1
Ligand SOU 1 x SOU
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-39858
Expression system: Homo sapiens

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