› 8zjf

Electron Microscopy
2.7Å resolution

Cryo-EM structure of human integrin alpha-E beta-7

Released:
DOI: 10.2210/pdb8zjf/pdb
PDB entry 8zjf coloured by chain, front view.
PDB entry 8zjf coloured by chain, side view.
PDB entry 8zjf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of I domain-containing integrin αEβ7.
Akasaka H, Sato D, Shihoya W, Nureki O, Kise Y
Biochem Biophys Res Commun 721 150121 (2024)
PMID: 38781659
Related structures: EMD-60143

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-245091 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Integrin beta-7 Chain: B
Molecule details ›
Chain: B
Length: 826 amino acids
Theoretical weight: 90.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P26010 (Residues: 2-798; Coverage: 100%)
Gene name: ITGB7
Sequence domains:
Integrin alpha-E Chain: A
Molecule details ›
Chain: A
Length: 1198 amino acids
Theoretical weight: 132.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P38570 (Residues: 2-1179; Coverage: 100%)
Gene name: ITGAE
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand MG 1 x MG
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-60143
Expression system: Homo sapiens

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