› 8zji

Electron Microscopy
4.23Å resolution

Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 1)

Released:
DOI: 10.2210/pdb8zji/pdb
PDB entry 8zji coloured by chain, front view.
PDB entry 8zji coloured by chain, side view.
PDB entry 8zji coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state.
Kukimoto-Niino M, Katsura K, Ishizuka-Katsura Y, Mishima-Tsumagari C, Yonemochi M, Inoue M, Nakagawa R, Kaushik R, Zhang KYJ, Shirouzu M
J Biol Chem 107459 (2024)
PMID: 38857861
Related structures: EMD-60146

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-158912 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Engulfment and cell motility protein 1 Chains: A, D
Molecule details ›
Chains: A, D
Length: 733 amino acids
Theoretical weight: 84.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92556 (Residues: 1-727; Coverage: 100%)
Gene names: ELMO1, KIAA0281
Sequence domains:
Dedicator of cytokinesis protein 5 Chains: B, E
Molecule details ›
Chains: B, E
Length: 1648 amino acids
Theoretical weight: 191.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H7D0 (Residues: 1-1642; Coverage: 88%)
Gene name: DOCK5
Sequence domains:
Ras-related C3 botulinum toxin substrate 1 Chains: C, F
Molecule details ›
Chains: C, F
Length: 184 amino acids
Theoretical weight: 20.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63000 (Residues: 1-177; Coverage: 92%)
Gene names: MIG5, RAC1, TC25
Sequence domains: Ras family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.23Å
Relevant EMDB volumes: EMD-60146
Expression systems:
  • Homo sapiens
  • Escherichia coli

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