› 8zsb

Electron Microscopy
3.26Å resolution

Cryo-EM structure of human ZnT1, in the absence of zinc, determined in outward-facing conformation

Released:
DOI: 10.2210/pdb8zsb/pdb
PDB entry 8zsb coloured by chain, front view.
PDB entry 8zsb coloured by chain, side view.
PDB entry 8zsb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Zinc transporter 1 functions in copper uptake and cuproptosis.
Li Y, Ma J, Wang R, Luo Y, Zheng S, Wang X
Cell Metab (2024)
PMID: 39111308
Related structures: EMD-60410

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-280358 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proton-coupled zinc antiporter SLC30A1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 507 amino acids
Theoretical weight: 55.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y6M5 (Residues: 1-507; Coverage: 100%)
Gene names: SLC30A1, ZNT1
Sequence domains: Cation efflux family

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.26Å
Relevant EMDB volumes: EMD-60410
Expression system: Homo sapiens

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