› 8zss

Electron Microscopy
3.07Å resolution

Cryo-EM structure of the RO5263397-bound hTAAR1-Gs complex

Released:
DOI: 10.2210/pdb8zss/pdb
PDB entry 8zss coloured by chain, front view.
PDB entry 8zss coloured by chain, side view.
PDB entry 8zss coloured by chain, top view.
Source organisms:
Primary publication:
The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.
Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S, Xu F
Cell Rep 43 114505 (2024)
PMID: 39002128
Related structures: EMD-60426

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-272611 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A
Molecule details ›
Chain: A
Length: 247 amino acids
Theoretical weight: 28.36 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 345 amino acids
Theoretical weight: 37.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Molecule details ›
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Sequence domains: GGL domain
Nb35 Chain: N
Molecule details ›
Chain: N
Length: 139 amino acids
Theoretical weight: 15.27 KDa
Source organism: Lama glama
Expression system: Escherichia
Soluble cytochrome b562; Trace amine-associated receptor 1 Chain: R
Molecule details ›
Chain: R
Length: 495 amino acids
Theoretical weight: 56.65 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
  • Canonical: Q96RJ0 (Residues: 2-339; Coverage: 100%)
Gene names: TA1, TAAR1, TAR1, TRAR1, cybC
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand A1D8X 1 x A1D8X
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.07Å
Relevant EMDB volumes: EMD-60426
Expression systems:
  • Spodoptera frugiperda
  • Escherichia

Quick links