› 8zu8

Electron Microscopy
3.9Å resolution

Human PIEZO1-A1988V

Released:
DOI: 10.2210/pdb8zu8/pdb
PDB entry 8zu8 coloured by chain, front view.
PDB entry 8zu8 coloured by chain, side view.
PDB entry 8zu8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human PIEZO1 and its slow inactivating channelopathy mutants.
Shan Y, Guo X, Zhang M, Chen M, Li Y, Zhang MF, Pei D
Elife (2024)
Related structures: EMD-60481

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-284383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Piezo-type mechanosensitive ion channel component 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1952 amino acids
Theoretical weight: 223.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92508 (Residues: 570-2521; Coverage: 77%)
Gene names: FAM38A, KIAA0233, PIEZO1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand L9Q 3 x L9Q
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-60481
Expression system: Homo sapiens

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