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Human PIEZO1-A1988V

Electron Microscopy
3.9Å resolution
PDB entry 8zu8 coloured by chain, front view.
PDB entry 8zu8 coloured by chain, side view.
PDB entry 8zu8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Piezo-type mechanosensitive ion channel component 1
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Multimeric state: homo trimer
Accessible surface area: 194920.77 Å2
Buried surface area: 17828.36 Å2
Dissociation area: 8,914.18 Å2
Dissociation energy (ΔGdiss): 111.37 kcal/mol
Dissociation entropy (TΔSdiss): 37.42 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-284383

Macromolecules

Piezo-type mechanosensitive ion channel component 1
Chains: A, B, C
Length: 1952 amino acids
Theoretical weight: 223.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92508 (Residues: 570-2521; Coverage: 77%)
Gene names: FAM38A, KIAA0233, PIEZO1
Pfam:
Piezo-type mechanosensitive ion channel component 1 in PDB entry 8zu8, assembly 1, front view.
Piezo-type mechanosensitive ion channel component 1 in PDB entry 8zu8, assembly 1, side view.
Piezo-type mechanosensitive ion channel component 1 in PDB entry 8zu8, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q92508  
119522004006008001,0001,2001,4001,6001,800
 
50010001500
UniProt
Q92508
Chains
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
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