› 8zyn

Electron Microscopy
3.27Å resolution

Cryo-EM Structure of inhibitor-free hERG Channel

Released:
DOI: 10.2210/pdb8zyn/pdb
PDB entry 8zyn coloured by chain, front view.
PDB entry 8zyn coloured by chain, side view.
PDB entry 8zyn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T
Structure (2024)
PMID: 39321803
Related structures: EMD-60573

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-gated inwardly rectifying potassium channel KCNH2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 820 amino acids
Theoretical weight: 91.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12809 (Residues: 1-1159; Coverage: 70%)
  • Best match: Q12809-6 (Residues: 24-460)
Gene names: ERG, ERG1, HERG, KCNH2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.27Å
Relevant EMDB volumes: EMD-60573
Expression system: Homo sapiens

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