PDB 9axf structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

G protein-coupled receptor activity

Biological process:

G protein-coupled receptor signaling pathway

Cellular component:

membrane

Structure analysis Details

Assembly composition:

hetero heptamer (preferred)

PDBe Complex ID:

PDB-CPX-544649 (preferred)

Entry contents:

6 distinct polypeptide molecules

Macromolecules (7 distinct):

Extracellular calcium-sensing receptor Chains: Q, R

Molecule details ›

Chains: Q, R
Length: 911 amino acids
Theoretical weight: 102.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P41180 (Residues: 1-903; Coverage: 84%)

Gene names: CASR, GPRC2A, PCAR1
Sequence domains:

Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A

Molecule details ›

Chain: A
Length: 246 amino acids
Theoretical weight: 28.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P63096 (Residues: 1-53, 229-242, 347-348; Coverage: 17%)
Canonical: P63092 (Residues: 207-251, 266-386, 389-394; Coverage: 44%)

Gene names: GNAI1, GNAS, GNAS1, GSP
Sequence domains: G-protein alpha subunit

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B

Molecule details ›

Chain: B
Length: 348 amino acids
Theoretical weight: 38.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P62873 (Residues: 2-340; Coverage: 100%)

Gene name: GNB1
Sequence domains: WD domain, G-beta repeat

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G

Molecule details ›

Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P59768 (Residues: 1-71; Coverage: 100%)

Gene name: GNG2
Sequence domains: GGL domain

Single-chain antibody fragment scFv16 Chain: H

Molecule details ›

Chain: H
Length: 297 amino acids
Theoretical weight: 31.87 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda

Nanobody Nb-35 Chain: N

Molecule details ›

Chain: N
Length: 160 amino acids
Theoretical weight: 17.35 KDa
Source organism: Lama glama
Expression system: Escherichia coli