› 9b1j

Electron Microscopy
3Å resolution

Urate bound human URAT1 in the inward-facing state

Released:
DOI: 10.2210/pdb9b1j/pdb
PDB entry 9b1j coloured by chain, front view.
PDB entry 9b1j coloured by chain, side view.
PDB entry 9b1j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transport mechanism and structural pharmacology of human urate transporter URAT1.
Dai Y, Lee CH
Cell Res (2024)
PMID: 39245778
Related structures: EMD-44081

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275277 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 22 member 12 Chain: A
Molecule details ›
Chain: A
Length: 547 amino acids
Theoretical weight: 59.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96S37 (Residues: 3-553; Coverage: 99%)
Gene names: OATL4, SLC22A12, UNQ6453/PRO34004, URAT1
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

3 bound ligands:
Ligand NAG 1 x NAG
Ligand URC 1 x URC
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-44081
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Lowering the risk of hyperuricemia and gout is associated with ideal cardiovascular health.
Liu et al. (2024)