› 9bbc

Electron Microscopy
3.3Å resolution

TCR GDN detergent micelle

Released:
DOI: 10.2210/pdb9bbc/pdb
PDB entry 9bbc coloured by chain, front view.
PDB entry 9bbc coloured by chain, side view.
PDB entry 9bbc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex.
Notti RQ, Yi F, Heissel S, Bush MW, Molvi Z, Das P, Molina H, Klebanoff CA, Walz T
bioRxiv (2024)
PMID: 37662363
Related structures: EMD-44417

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-525380 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (8 distinct):
T cell receptor alpha chain constant Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 30.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01848 (Residues: 1-139; Coverage: 99%)
Gene names: TCRA, TRAC
Sequence domains: Domain of unknown function (DUF1968)
T cell receptor beta constant 1 Chain: B
Molecule details ›
Chain: B
Length: 305 amino acids
Theoretical weight: 33.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01850 (Residues: 1-172; Coverage: 98%)
Gene name: TRBC1
Sequence domains: Immunoglobulin C1-set domain
T-cell surface glycoprotein CD3 delta chain Chain: D
Molecule details ›
Chain: D
Length: 171 amino acids
Theoretical weight: 18.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04234 (Residues: 1-171; Coverage: 100%)
Gene names: CD3D, T3D
Sequence domains:
T-cell surface glycoprotein CD3 epsilon chain Chains: E, F
Molecule details ›
Chains: E, F
Length: 207 amino acids
Theoretical weight: 23.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P07766 (Residues: 1-207; Coverage: 100%)
Gene names: CD3E, T3E
Sequence domains:
T-cell surface glycoprotein CD3 gamma chain Chain: G
Molecule details ›
Chain: G
Length: 137 amino acids
Theoretical weight: 15.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09693 (Residues: 1-137; Coverage: 72%)
Gene names: CD3G, T3G
Sequence domains: T-cell surface glycoprotein CD3 delta chain
T-cell surface glycoprotein CD3 zeta chain Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 164 amino acids
Theoretical weight: 18.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20963 (Residues: 1-164; Coverage: 100%)
Gene names: CD247, CD3Z, T3Z, TCRZ
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 5 x NAG
Ligand CLR 2 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-44417
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Recent advances in understanding TCR signaling: a synaptic perspective.
Dustin ML. (2023)