› 9c2f

Electron Microscopy
2.8Å resolution

Structure of Calcium-Sensing Receptor in complex with positive allosteric modulator '54149

Released:
DOI: 10.2210/pdb9c2f/pdb
PDB entry 9c2f coloured by chain, front view.
PDB entry 9c2f coloured by chain, side view.
PDB entry 9c2f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large library docking identifies positive allosteric modulators of the calcium-sensing receptor.
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Science 385 eado1868 (2024)
PMID: 39298584
Related structures: EMD-45156

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273705 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Extracellular calcium-sensing receptor Chain: A
Molecule details ›
Chain: A
Length: 959 amino acids
Theoretical weight: 108.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41180 (Residues: 19-894; Coverage: 83%)
Gene names: CASR, GPRC2A, PCAR1
Sequence domains:
Extracellular calcium-sensing receptor Chain: B
Molecule details ›
Chain: B
Length: 939 amino acids
Theoretical weight: 105.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41180 (Residues: 19-894; Coverage: 83%)
Gene names: CASR, GPRC2A, PCAR1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
5 bound ligands:
Ligand NAG 5 x NAG
Ligand CA 8 x CA
Ligand TRP 2 x TRP
Ligand PO4 2 x PO4
Ligand A1ATX 2 x A1ATX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-45156
Expression system: Spodoptera frugiperda

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