› 9cz7

X-ray diffraction
2.57Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-529797 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (7 distinct):
Integrin alpha-V heavy chain Chain: A
Molecule details ›
Chain: A
Length: 605 amino acids
Theoretical weight: 66.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P06756 (Residues: 31-625; Coverage: 58%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Integrin beta-6 Chain: B
Molecule details ›
Chain: B
Length: 481 amino acids
Theoretical weight: 52.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P18564 (Residues: 22-491; Coverage: 61%)
Gene name: ITGB6
Sequence domains:
17E6 Fab light chain Chain: C
Molecule details ›
Chain: C
Length: 214 amino acids
Theoretical weight: 23.72 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
17E6 Fab heavy chain Chain: D
Molecule details ›
Chain: D
Length: 218 amino acids
Theoretical weight: 23.21 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
6 bound ligands:
Ligand CA 6 x CA
Ligand GOL 8 x GOL
Ligand MG 1 x MG
Ligand A1A6A 1 x A1A6A
Ligand NAG 2 x NAG
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS-II BEAMLINE 17-ID-1
Spacegroup: P212121
Unit cell:
a: 96.494Å b: 132.501Å c: 168.366Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.234
Expression system: Homo sapiens

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