› 9ekf

Electron Microscopy
2.68Å resolution

CryoEM structure of H5N1 A/Texas/37/2024 HA bound to Fab 65C6 and an auto glycan occupying the receptor-binding site

Released:
DOI: 10.2210/pdb9ekf/pdb
PDB entry 9ekf coloured by chain, front view.
PDB entry 9ekf coloured by chain, side view.
PDB entry 9ekf coloured by chain, top view.
Source organisms:
Primary publication:
Structure of a zoonotic H5N1 hemagglutinin reveals a receptor-binding site occupied by an auto-glycan.
Morano NC, Guo Y, Becker JE, Li Z, Yu J, Ho DD, Shapiro L, Kwong PD
Structure (2025)
PMID: 39884273
Related structures: EMD-48120

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-286420 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 576 amino acids
Theoretical weight: 65.59 KDa
Source organism: Influenza A virus
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A8E4ZAK5 (Residues: 1-520; Coverage: 92%)
Gene name: HA
Sequence domains: Haemagglutinin
Fab 65C6 Heavy Chain Chains: D, G, H
Molecule details ›
Chains: D, G, H
Length: 237 amino acids
Theoretical weight: 25.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab 65C6 Light Chain Chains: I, K, L

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, SIA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.68Å
Relevant EMDB volumes: EMD-48120
Expression system: Homo sapiens

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